Sam didn't know Regina all that well, but she'd seemed to treat him more like a colleague than anything from the beginning. And with her being so close to Rebekah, he'd gotten a few insights into the woman that he didn't figure most people, even telepathic people, had.

"She's upset because there's nothing she can do to protect us and she doesn't know whether the people who left are safe or in more danger. I'm pretty sure she'd really appreciate someone asking for her help right now or showing her something that she needs to do."